RecruitingPhase 1ACTRN12606000056594

Recurrence of varicose veins following superficial venous surgery: prevention using doxycycline

Sponsor

Department of Surgery, Dunedin school of medicine.

Enrollment

10 participants

Start Date

Feb 1, 2006

Study Type

Interventional

Conditions

Recurrence of varicose veins

Summary

Double blinding:Main study only: Patients will be given doxycycline or placebo in identical bottles. Research staff involved in measurements will not be aware of the group getting doxycycline, although doctors involved in care of patient (eg GPs) will be notified. Primary goal of the main study will be to determine whether doxycycline is able to prevent neovascularisation in patients following superficial venous surgery.

Eligibility

Sex: Both males and femalesMin Age: 16 YearssMax Age: 75 Yearss

Plain Language Summary

Simplified for easier understanding

This study is testing whether a common antibiotic called doxycycline can prevent varicose veins from growing back after surgery. After varicose vein surgery, new small blood vessels sometimes grow back and can cause the veins to return. Doxycycline may help prevent this from happening. Participants will receive either doxycycline or a dummy pill (placebo) without knowing which one they are taking. You may be eligible if: - You are between 16 and 75 years old - You are scheduled for varicose vein surgery (including saphenofemoral ligation) You may NOT be eligible if: - Your life expectancy after surgery is less than 2 years - You live far from Dunedin and cannot attend follow-up appointments - You have severe problems with mobility - You have previously had a bad reaction to doxycycline or other tetracycline antibiotics Talk to your doctor about whether this trial might be right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Pilot study: A randomised controlled double blind study of the use of doxycycline to affect levels of CD34 positive cells, VEGF, MMP-9 and other factors following abdominal aortic aneurysm repair. Gr

Pilot study: A randomised controlled double blind study of the use of doxycycline to affect levels of CD34 positive cells, VEGF, MMP-9 and other factors following abdominal aortic aneurysm repair. Grp A: patients will take doxycycline (100mg twice daily) for one week prior to surgery and 4 weeks post operatively. Grp B: patients will take doxycycline (100mg twice daily) beginning on the day of surgery and for 4 weeks post operatively. Blood samples will be taken prior to, during and after doxycycline administration. Tissue samples will be obtained following surgery. Main study: A randomised controlled double blind study of the use of doxycycline to affect levels of CD34 positive cells, VEGF, MMP-9 and other factors following superficial venous surgery for varicose veins. Details of this study will be expanded on when results of the pilot study have been analysed. Follow up of all patients with ultrasound, air plethysmography and clinical evaluation at 1 month, 6 months, 1, 3 and 5 years.

Locations(1)

New Zealand

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ACTRN12606000056594