Not Yet RecruitingPhase 3ACTRN12606000057583

Improving blood coagulation function and reducing blood loss in infants after open heart surgery

Effect of nitric oxide gas and prostacyclin infusion on platelet function, coagulation activity and postoperative blood loss in paediatric cardiopulmonary bypass

Sponsor

Royal Childrens Hospital and Murdoch Children's Research Institute

Enrollment

80 participants

Start Date

Apr 3, 2006

Study Type

Interventional

Conditions

Haemostasis during and after paediatric cardiopulmonary bypass

Eligibility

Sex: Both males and femalesMin Age: 0 YearssMax Age: 1 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying: Improving blood coagulation function and reducing blood loss in infants after open heart surgery. It may be open to people aged 1 or younger. Participation typically involves medical assessments, possible treatment with the study intervention, and follow-up visits to track your health.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

This study will compare 4 anticoagulation treatments in infants during cardiac surgery with cardiopulmonary bypass: 2) anticoagulation with intravenous heparin 3 mg/kg plus 20 ppm nitric oxide (NO)

This study will compare 4 anticoagulation treatments in infants during cardiac surgery with cardiopulmonary bypass: 2) anticoagulation with intravenous heparin 3 mg/kg plus 20 ppm nitric oxide (NO) gas added to the oxygenator 3) anticoagulation with intravenous heparin 3 mg/kg plus intravenous infusion of prostacyclin 2 ng/kg/min 4) anticoagulation with intravenous heparin 3 mg/kg plus combination of 20 ppm NO gas added to oxygenator and intravenous infusion of prostacyclin 2 ng/kg/min

Locations(1)

Australia

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ACTRN12606000057583