Dietary fish oil and post surgical atrial fibrillation
Use of n-3 polyunsaturated fatty acids to reduce post surgical atrial fibrillation: A prospective randomised study
Royal Adelaide Hospital
600 participants
Apr 11, 2006
Interventional
Conditions
Summary
Patients undergoing cardiac surgery for coronary artery bypass or valve repair/replacement are at risk of a number of complications. One of the most common complications is atrial fibrillation (AF), or abnormal contraction of the upper chamber of the heart, which occurs in about 30% to 55% of patients, depending on the type of surgery. While AF itself is not particularly dangerous, it does lead to increased length of stay in hospital, with associated costs, and also increases the risk of stroke. Patients suffering from post-surgical AF are generally prescribed additional medications, some of which can have unpleasant side effects. The purpose of this study is to determine whether fish oil given prior to surgery reduces the risk of developing AF after surgery. We also plan to investigate a number of mechanisms by which fish oil may exert its cardio-protective properties
Eligibility
Plain Language Summary
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Interventions
Dietary fish oil or high monounsaturated sunflower oil commencing 3 weeks prior to surgery. If surgery is postponed after commencing the intervention, then treatment will continue until surgery. There is no maximum period of the intervention. the dose is 15 ml/day and is supplied as bulk liquid in 500 ml bottles. subjects are instructed to take the oil on juice
Locations(1)
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ACTRN12606000134527