ActivePhase 2Phase 3ACTRN12606000134527

Dietary fish oil and post surgical atrial fibrillation

Use of n-3 polyunsaturated fatty acids to reduce post surgical atrial fibrillation: A prospective randomised study


Sponsor

Royal Adelaide Hospital

Enrollment

600 participants

Start Date

Apr 11, 2006

Study Type

Interventional

Conditions

Summary

Patients undergoing cardiac surgery for coronary artery bypass or valve repair/replacement are at risk of a number of complications. One of the most common complications is atrial fibrillation (AF), or abnormal contraction of the upper chamber of the heart, which occurs in about 30% to 55% of patients, depending on the type of surgery. While AF itself is not particularly dangerous, it does lead to increased length of stay in hospital, with associated costs, and also increases the risk of stroke. Patients suffering from post-surgical AF are generally prescribed additional medications, some of which can have unpleasant side effects. The purpose of this study is to determine whether fish oil given prior to surgery reduces the risk of developing AF after surgery. We also plan to investigate a number of mechanisms by which fish oil may exert its cardio-protective properties


Eligibility

Sex: Both males and femalesMin Age: 18 Yearss

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying: Dietary fish oil and post surgical atrial fibrillation. It may be open to adults aged 18 and older who meet certain criteria, including: Elective coronary bypass surgery (CABG and/or valve repair/replacement surgery)• Informed consent. Participation typically involves medical assessments, possible treatment with the study intervention, and follow-up visits to track your health.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Dietary fish oil or high monounsaturated sunflower oil commencing 3 weeks prior to surgery. If surgery is postponed after commencing the intervention, then treatment will continue until surgery. There

Dietary fish oil or high monounsaturated sunflower oil commencing 3 weeks prior to surgery. If surgery is postponed after commencing the intervention, then treatment will continue until surgery. There is no maximum period of the intervention. the dose is 15 ml/day and is supplied as bulk liquid in 500 ml bottles. subjects are instructed to take the oil on juice


Locations(1)

Australia

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ACTRN12606000134527