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CompletedPhase 2Phase 3ACTRN12606000232538

The early use of IV (Intra venous)verapamil and nitrates in Acute Myocardial Infarction (AMI)

The early use of Intra Venous verapamil and nitrates and the effects on angiographic patency and infarct size in Acute Myocardial Infarction

Sponsor

The Queen Elizabeth Hospital,Cardiology Unit

Enrollment

300 participants

Start Date

Oct 1, 2005

Study Type

Interventional

Conditions

Acute ST segment elevation myocardial infarction requiring urgent revascularisation (angioplasty or stent). The ST segment refers to that of QRST complex as represented on a 12 lead ECG(electrocardiogragh)

Summary

To assess if the early use of verapamil and Glyceryl trinitrate improves TIMI 3 flow(term used to state that blood flow through coronary artery is back to normal)Only the study pharmacist was unblinded to treatment allocation. Study drug was sealed in a box and allocated a number in lots of 10. Study staff would allocate the sealed box to the patient by number sequence. All study personel and persons involved in the clinical management of the patient were also blinded to treatment allocation.Emergency unblinding was available if required.

Eligibility

Sex: Both males and femalesMin Age: 18 Yearss

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying: The early use of IV (Intra venous)verapamil and nitrates in Acute Myocardial Infarction (AMI). The study is looking for participants who meet specific health criteria. Participants must be at least 18 Years old. Participation likely involves regular medical check-ups and monitoring by the study team.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

IV verapamil 2 mg over 5 minutes or saline placebo and glyceryl trinitrate infusion 5mcg per minute( 8 mls per hour) and the patient has given informed consent.

IV verapamil 2 mg over 5 minutes or saline placebo and glyceryl trinitrate infusion 5mcg per minute( 8 mls per hour) and the patient has given informed consent.

Locations(1)

Australia

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ACTRN12606000232538