The treatment of depression in Parkinson's Disease using mifepristone.

This study is testing whether a medication called mifepristone can treat depression in people with Parkinson's disease. Depression affects many people with Parkinson's but is often hard to treat. Mifepristone works differently from typical antidepressants by blocking certain stress hormones. Participants will take the study drug and a dummy pill (placebo) in two separate periods, with neither the researchers nor the participants knowing which is which. You may be eligible if: - You have a confirmed diagnosis of Parkinson's disease - You have been diagnosed with a major depressive episode (by DSM-IV criteria) - Your memory and thinking score (MMSE) is above 23 - You are 18 years or older You may NOT be eligible if: - Your depression is severe with active thoughts of suicide requiring urgent treatment - You currently use steroid medications - You have severe asthma or other serious breathing problems - You have chronic adrenal, kidney, or liver failure - You are a woman of childbearing potential (women past menopause or post-surgical menopause are eligible) Talk to your doctor about whether this trial might be right for you.