The efficacy of intranasal administration of Naloxone by paramedics for the successful treatment of suspected heroin overdose in the prehospital setting.
Department of Human Services, Australian Government.
200 participants
Aug 1, 2006
Interventional
Conditions
Summary
The purpose of this study is to determine the effectiveness of concentrated intranasal naloxone compared to intramuscular naloxone for treatment by paramedics of respiratory depression due to suspected opiate overdose in the pre-hospital setting. Subjects are unconscious prior to study enrolment, and consent from individuals for study participation is not required.
Eligibility
Plain Language Summary
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Interventions
Randomisation to receive either intramuscular naloxone 2mg or intranasal naloxone 2mg via a mucosal atomisation device [MAD]. Subjects receive one dose only of intranasal naloxone before re-assessment at 10 minutes post treatment. Subjects are given additional intramuscular Naloxone after 10 minutes if clinically necessary. Duration of the study is likely to be 18 months, commencing 1st August 2006 and concluding 31st January 2008.
Locations(1)
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ACTRN12606000322538