A randomised, double blind, placebo controlled, parallel trial of folic acid and the improvement of endothelial dysfunction in obese children and adolescents
Effects of folic acid on endothelial function in obese children and adolescents
Children, Youth and Women's Health Service
60 participants
Jan 2, 2004
Interventional
Conditions
Summary
Worldwide obesity has increased over the last decade. Paediatric obesity is known to be an independent risk factor for adult obesity. Adolescent obesity is associated with atherosclerosis. Atherosclerosis is preceded by endothelial or blood vessel dysfunction that can be assessed by ultrasound. Endothelial dysfunction occurs in severely obese children. Early interventions to improve endothelial dysfunction in obesity, in addition to metabolic and weight control may potentially prevent atherosclerosis and heart disease. Folic acid has been proposed as one of the strategies to reduce atherosclerosis and hasn't been investigated in obesity.
Eligibility
Inclusion Criteria1
- Obese children.
Exclusion Criteria1
- Current or recent use of Vitamin B or folic acid supplements, metformin, orlistat, Angiotensin Converting Enzyme inhibitiors, HMGCoA reductase inhibitors, and/or antihyoertensive treatment. Vitamin B12 deficiency. Smoking. Hypertension. Type 2 diabetes according to World Health Organization criteria. Endocrinological or syndromal causes of obesity.
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
5 mg oral folic acid taken daily for 8 weeks
Locations(1)
View Full Details on ANZCTR
For the most up-to-date information, visit the official listing.
ACTRN12606000457549