The effect of propofol or propofol plus midazolam and/or fentanyl on cognitive impairment following colonoscopy
Melbourne Health Research Directorate
200 participants
Dec 6, 2006
Interventional
Conditions
Summary
Patients having colonoscopy under sedation may remain sedated for some hours afterwards. This may mean that they cannot return to work inside or outside the home. Our hypothesis is that patients who receive midazolam and fentanyl, as well as propofol, will be more sedated than those who receive propofol alone, at the time of hospital discharge.
Eligibility
Inclusion Criteria1
- Patients who present for elective outpatient colonoscopy, not combined with other procedures and following full bowel preparation.
Exclusion Criteria1
- Patients with cognitive deficits and without adequate English language comprehension.
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Interventions
2. Sedation individually titrated for patient requirement for the duration of colonoscopy (10-60 minutes) with variable dose intravenous propofol (50-400 mg) plus variable dose intravenous midazolam (0.5-5 mg) and/or variable dose intravenous fentanyl (10-100 mcg)
Locations(1)
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ACTRN12606000503527