Oral analgesia compared with intrathecal morphine for pain after caesarean delivery: a randomised controlled trial
Oral oxycodone analgesia compared with intrathecal morphine for pain relief after caesarean delivery: a randomised controlled trial
Individual (Michael Paech)
120 participants
Jan 21, 2007
Interventional
Conditions
Summary
This study will investigate two methods of pain relief after caesarean section conducted under regional anaesthesia. Our hypothesis is that multimodal analgesia including intrathecal morphine is more effective than multimodal analgesia with regular administration of oral opioid.
Eligibility
Inclusion Criteria1
- Elective or non-elective caesarean section under combined spinal-epidural or spinal anaesthesia American Society of Anesthesiologists classification 1 or 2
Exclusion Criteria1
- Preoperative opioid useContraindication, allergy or known intolerance to study drugsPreoperative nausea or pruritusFailure to identify the subarachnoid space or accidental dural puncture with the epidural needleRequirement for intraoperative opioid or epidural analgesic other than local anaesthetic Conversion to general anaesthesia.
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Interventions
Intervention group: Intrathecal morphine 100 mcg given with spinal anaesthesia immediately preoperatively. Both control group and intervention groups also receiving oral paracetamol 1 g in recovery and 6 hourly until 24 hours postoperatively plus diclofenac 100 mg per rectum at completion of surgery and diclofenac 50 mg orally 8 hourly until 24 hours postoperatively, after caesarean section.
Locations(1)
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ACTRN12606000506594