Oxygen therapy in severe asthma
A randomised controlled trial of the effect of high flow versus titrated oxygen therapy on carbon dioxide (CO2) levels in acute severe asthma
Medical Research Institute of New Zealand
150 participants
Mar 1, 2007
Interventional
Conditions
Summary
Current standard treatment is to provide high flow oxygen to people with severe asthma. However high flow oxygen may be detrimental and few studies have looked at the use of high flow oxygen in asthma. An alternative treatment is one where the amount of oxygen received is varied depending on the oxygen level in the blood. This study compares these two treatments.
Eligibility
Inclusion Criteria1
- History of asthma; Presentation to the emergency department with an acute exacerbation of asthma; Forced expiratory volume in 1 second (FEV1) less than or equal to 50% predicted
Exclusion Criteria1
- Diagnosis of Chronic obstructive pulmonary disease (COPD)/emphysema; Asthma attack requiring mechanical ventilation; Patient unconscious, unable to speak or unable to perform spirometry on arrival; Known or suspected chronic hypercapnic respiratory failure as a result of any of the following disorders - neuromuscular disease, chest wall disease, obesity hypoventilation syndrome.
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Interventions
Patients will be randomly assigned to receive one of 2 oxygen regimes for 1 hour: Continuous high flow oxygen (8L/min via Hudson mask).
Locations(1)
View Full Details on ANZCTR
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ACTRN12607000131459