RecruitingACTRN12607000207415

Transthoracic Echocardiography and Transurethral Resection of the Prostate

High dose versus low dose fluid preloading and the effect on left ventricular volume and function prior to the administration of spinal anaesthesia in patients undergoing transurethral resection of the prostate.

Sponsor

Department of Anaesthesia St Vincent's Hospital Melbourne

Enrollment

60 participants

Start Date

Apr 2, 2007

Study Type

Interventional

Conditions

Left ventricular volume and left ventricular function in patients undergoing transurethral resection of the prostate.

Summary

The primary purpose of this study is to find out what dose of intravenous fluid maintains enough fluid volume in the body after a spinal anaesthetic. Particpiants in this study are randomly assigned to have a high dose of intravenous fluid or a low dose of intravenous fluid. We find out how much fluid is in the body by doing an ultrasound of the heart before the the intravenous fluid is given, after the intravenous fluid is given, after the spinal anaesthetic is given and at the end of the operation.

Eligibility

Sex: MalesMin Age: 18 Yearss

Plain Language Summary

Simplified for easier understanding

This study is for men having elective surgery to treat an enlarged prostate (transurethral resection of the prostate, or TURP). It investigates how much intravenous (drip) fluid is needed to keep the body in the right fluid balance after receiving a spinal anaesthetic (numbing injection in the back). The study uses heart ultrasound (echocardiography) to measure fluid levels in the body at different points during the procedure. Participants are randomly given either a high or a low dose of intravenous fluid. You may be eligible if: - You are male and 18 years of age or older - You are having an elective (planned) transurethral resection of the prostate You may NOT be eligible if: - You have a medical reason why you cannot have a spinal anaesthetic - You need detailed heart monitoring (invasive cardiac monitoring) during the procedure Talk to your doctor about whether this trial might be right for you.

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Interventions

All patients receive 5 ml/kg of 0.9% sodium chloride as a standard fluid loading regime. The intervention group receives a further 10 ml/kg of 0.9% sodium chloride intravenously. The intravenous

All patients receive 5 ml/kg of 0.9% sodium chloride as a standard fluid loading regime. The intervention group receives a further 10 ml/kg of 0.9% sodium chloride intravenously. The intravenous fluid is administered until each patient has reached the specific amount calculated by thier weight. The spinal anaesthesia is performed once the fluid loading and the transthoracic echocardiography has been completed.

Locations(1)

Australia

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ACTRN12607000207415