Young women and weight loss study 2007

This study is for young women who are overweight or obese and want to lose weight. It tests whether an internet-based lifestyle program using a high-protein diet works better than the medication metformin or a placebo (dummy pill) for achieving and maintaining weight loss over one year. The study also looks at the effects of weight loss on reproductive health, metabolism, and nutritional status. You may be eligible if: - You are female, between 18 and 35 years old - Your BMI is between 25 and 40 kg/m² - You are generally healthy with no major chronic diseases - You are available for the full 1 year of the study - You have access to the internet - You are willing to be assigned to any of the study groups You may NOT be eligible if: - You have heart disease, diabetes (type 1 or 2), uncontrolled high blood pressure, kidney disease, liver disease, or thyroid problems - You are being treated for an eating disorder - You are currently receiving fertility treatment - You are pregnant or breastfeeding - You have a history of heavy alcohol use - You have had a known bad reaction to metformin - You are currently losing weight rapidly Talk to your doctor about whether this trial might be right for you.