RecruitingPhase 3ACTRN12607000225415

Efficacy of intravitreal triamcinolone acetonide before pan retinal photocoagulation for improvement of visual acuity and macular edema in diabetic retinopathy


Sponsor

Eye Research Center, Farabi Eye Hospital

Enrollment

60 participants

Start Date

Nov 1, 2005

Study Type

Interventional

Conditions

Summary

Purpose was to evaluate efficacy of intravitreal triamcinolone acetonide before pan retinal photocoagulation for improvement of visual acuity and macular edema in diabetic retinopathy. Our hypothesis is that triamcinolone acetonide before PRP helps for decreasing macular edema and improvement of visual acuity


Eligibility

Sex: Both males and femalesMin Age: 18 Yearss

Plain Language Summary

Simplified for easier understanding

This study is testing whether giving a steroid injection (triamcinolone acetonide) into the eye before laser treatment (called pan retinal photocoagulation) can protect eyesight and reduce swelling in the back of the eye for people with a serious form of diabetic eye disease called diabetic retinopathy. The researchers believe the steroid may help control swelling in the part of the eye responsible for sharp vision (the macula), leading to better vision outcomes after laser treatment. You may be eligible if: - You have diabetes - You have been diagnosed with severe non-proliferative or proliferative diabetic retinopathy - Both of your eyes are at the same stage of the disease, whether or not you have a type of macular swelling called CSME - You are 18 years of age or older You may NOT be eligible if: - Your retina has pulled away from the back of the eye (tractional retinal detachment) - You have glaucoma (increased eye pressure) - Your eye pressure rises in response to steroid treatment (corticosteroid responder) - You have an active infection or disease on the surface of the eye - There is something blocking the view of the back of your eye (media opacity) Talk to your doctor about whether this trial might be right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Patients with Severe NPDR or PDR who need panretinal photocoagulation(PRP) and have macular edema with same stage in both eyes are randomized to two groups. One eye is in the injection group The other

Patients with Severe NPDR or PDR who need panretinal photocoagulation(PRP) and have macular edema with same stage in both eyes are randomized to two groups. One eye is in the injection group The other eye is active control. in the first group 4 mg triamcinolone acetonide is injected intravitreally 1 week before first session of PRP . PRP is done in 3 sessions 1 week apart.


Locations(1)

Iran, Islamic Republic Of

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ACTRN12607000225415