Bacterial Vaginosis Antibiotic Probiotic Study
A randomised placebo-controlled trial to test the addition of vaginal clinidamycin or probiotic to oral metronidazole in the treatment of bacterial vaginosis
Bayside Health
450 participants
Sep 1, 2007
Interventional
Conditions
Summary
To determine if the addition of either topical clindamycin or a topical probiotic/oestrogen combination, reduces recurrent rates of bacterial vaginosis (BV), when added to the current recommended therapy of seven days of the oral antibiotic metronidazole. Hypotheses 1. Combination antibiotic therapy of oral metronidazole with vaginal clindamycin will be more effective than oral metronidazole alone in the treatment of bacterial vaginosis. 2. Restoring normal vaginal acidity and healthy bacteria through replacement of Lactobacillus bacteria and topical oestrogen (in addition to oral metronidazole), will achieve higher rates of cure than current recommended therapy oral metronidazole alone.
Eligibility
Plain Language Summary
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Interventions
3 armed trial. All women received 400mg twice daily oral metronidazole for 7 days, and concurrently randomised to also receive either vaginal topical 2% clindamycin cream (1 applicator full once daily for 7 days); vaginal topical probiotic (L.acidophilus KS400)/0.03mg oestriol pessary (one pessary once daily for 12 days) or placebo pessary (one pessary once daily for 12 days).
Locations(1)
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ACTRN12607000350426