Does dexamethasone influence blood cortisol levels after laparoscopic cholecystectomy?
Dexamethasone administration for postoperative nausea and vomiting in laparoscopic cholecystectomy and perioperative cortisol levels.
St Vincents Health Melbourne
40 participants
Sep 1, 2007
Interventional
Conditions
Summary
The primary endpoint of the study is to determine if dexamethasone 8mg, administered at the start of an anaesthetic to prevent postoperative nausea and vomiting, reduces the level of cortisol postoperatively. Cortisol is a hormone produced by the adrenal glands in times of stress (such as at operation). Dexamethasone is frequently used to prevent nausea and vomiting after operations and is known to reduce cortisol levels in patients not having operations.
Eligibility
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Interventions
Dexamethasone 8mg once only intravenously at commencement of anaesthesia for laparoscopic cholecystectomy. All participants (both active and control groups) receive tropisetron 2mg intravenously at the completion of surgery. Dexamethasone and tropisetron are used to prevent postoperative nausea and vomiting.
Locations(1)
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ACTRN12607000406404