A randomised trial to see if closing the arterial duct improves outcome in very premature babies

This study is looking at whether treating a common heart condition in very premature babies — called patent ductus arteriosus (PDA) — actually improves their outcomes. A PDA is when a small blood vessel near the heart that normally closes at birth stays open. Although this is routinely treated with a drug called indomethacin, there is limited evidence that treatment actually helps. This pilot study will help determine if a larger international study to answer this question is feasible. You may be eligible if: - Your baby was born weighing less than 1,250 grams OR at less than 28 weeks of pregnancy - Your baby has been found by ultrasound (echocardiography) to have a large patent ductus arteriosus at 3 days of age You may NOT be eligible if: - Your baby has significant birth defects - Your baby's condition is considered life-threatening in the next few hours - Your baby has already received indomethacin - There is a medical reason your baby cannot receive indomethacin Talk to your doctor about whether this trial might be right for you.