A Prospective Study Investigating the Impact of Definitive Chemoradiation in Locally and/or Regionally Advanced Squamous Cell Carcinoma of the Skin

Phase 2 This is a study of the effectiveness and toxicity of chemoradiation therapy for skin cancer (squamous cell carcinoma). Who is it for? You can join this study if you have squamous cell skin cancer that cannot be treated surgically. Trial details Participants will receive chemotherapy with the drugs cisplatin or carboplatin once per week for 6 weeks as well as daily radiotherapy. There is no control group in this study. Participants' response to treatment will be measured 8 weeks after treatment is completed. Side effects will be monitored during treatment, at 4, 8 and 12 weeks after treatment is completed, and then every 2 months for the first year, and every three months after that. Overall survival and disease free survival will be measured after 3 years. The study aims to document the effectiveness and toxicity of treatment with combined chemotherapy and radiotherapy.