RecruitingACTRN12607000586415
Metabolic Effects of SERMs (Selective Oestrogen Receptor Modulators) in healthy men and healthy postmenopausal women
Sponsor
Department of Endocrinology, St Vincent's Hospital
Enrollment
24 participants
Start Date
Nov 27, 2006
Study Type
Interventional
Conditions
Summary
We aim to investigate and compare the effects of raloxifene and tamoxifen (two most commonly used SERMs) in healthy men and women on the growth hormone system and metabolism.
Eligibility
Sex: Both males and femalesMin Age: 50 YearssMax Age: 80 Yearss
Inclusion Criteria1
- Healthy postmenopausal women and healthy men the same age
Exclusion Criteria1
- obesity, diabetes, cancer, kidney or liver diseases, deep vein thrombosis
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Interventions
Raloxifene 60mg and 120 mg daily and Tamoxifen 10 mg and 20 mg daily. Duration of treatment for each dose is 2 weeks with washout period of 2 weeks after cross over.
Raloxifene 60mg and 120 mg daily and Tamoxifen 10 mg and 20 mg daily. Duration of treatment for each dose is 2 weeks with washout period of 2 weeks after cross over.
Locations(1)
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ACTRN12607000586415