A study looking at the effect positron emission tomography (PET) scans have on the treatment decisions specialists make in patients with suspected cancer of the pancreas.
A prospective study investigating the impact of the addition of FDG-PET/CT on treatment decisions compared to standard pre-operative work up for patients with suspected pancreatic, peri-ampullary or bile duct malignancies
Royal Brisbane Hospital
90 participants
Jan 15, 2008
Interventional
Conditions
Summary
In addition to the standard pre-operative investigations you will also undergo a PET scan. Your results will be compared to people who only receive the routine pre-operative investigations, to see if the use of the PET scan changes the treatment plan. A PET scan is a non-invasive nuclear imaging test. In other cancers, particularly lung cancer, this scan can detect the spread of cancer better than other tests. If you have a suspected pancreatic cancer, the usual tests might include a CT (computed tomography) scan, ultrasound, MRI (magnetic resonance imaging) scan and an ERCP (endoscopic retrograde cholangiopancreatography). If a PET scan helps show the extent of the cancer better, your diagnosis will be more accurate and this might spare you unnecessary major surgery.
Eligibility
Inclusion Criteria5
- Suspected or proven localized pancreatic, ampullary or bile duct malignancy on the basis of standard investigations;
- = 18 years old;
- Deemed suitable, based on tumour stage and medical fitness, to potentially undergo surgery or radiotherapy with curative intent;
- Available for follow up for at least 12 months from the date of PET/CT scanning;
- Able to provide Informed Consent.
Exclusion Criteria6
- Claustrophobia;
- Uncontrolled diabetes mellitus;
- Pregnancy;
- Unable to provide informed consent;
- Inability to undergo PET/CT study;
- Any disease, condition, physical examination finding or clinical laboratory finding which, in the opinion of the investigator, makes the patient inappropriate for the study.
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Interventions
Adding 18 fluorodeoxyglucose positron emission tomography (FDG-PET) which,in other cancers, is better able to pick up cancer spread than other tests are. This scan will be done once at the time of diagnosis and staging.
Locations(1)
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ACTRN12607000604404