Australasian Resuscitation In Sepsis Evaluation Randomised Controlled Trial

This large study is testing whether a specific intensive treatment protocol called Early Goal-Directed Therapy (EGDT) reduces the risk of death in people who arrive at hospital emergency departments with severe sepsis (a life-threatening response to infection). EGDT involves very closely monitoring and adjusting blood flow and oxygen levels in the body during the first 6 hours after diagnosis. The study will compare this approach to standard emergency care across 32 hospitals in Australia and New Zealand. You may be eligible if: - You are 18 years of age or older - You are in an emergency department with a suspected or confirmed infection - You meet criteria for a serious body-wide inflammatory response (SIRS) - You show signs of low blood pressure or poor blood flow that is not responding to initial treatment You may NOT be eligible if: - There is a medical reason you cannot have a central venous catheter (a tube placed in a large vein) - You are unable to receive blood products - You are actively and severely bleeding - You are pregnant - You have a terminal illness with a life expectancy under 90 days - Your death is considered imminent - You transferred from another hospital Talk to your doctor about whether this trial might be right for you.