Not Yet RecruitingPhase 3Phase 4ACTRN12608000088347
Post Amputation Phantom Limb Pain Study
Can Pregabalin prevent persistent post amputation pain?
Sponsor
John Hunter Hospital-Hunter Integrated Pain Service
Enrollment
120 participants
Start Date
Mar 1, 2008
Study Type
Interventional
Conditions
Summary
The aim of the study is to determine whether the use of the drug Pregabalin can reduce or eliminate phantom pain after leg amputations
Eligibility
Sex: Both males and femalesMin Age: 18 YearssMax Age: 0 N/As
Inclusion Criteria3
- Patient able to provide own informed consent.
- there is sufficient ime before proposed surgery to allow absorption of loading dose of pregabalin, minimum 2hrs
- Patient is suitable for standard general anaesthetic (GA) regimen and able to use patient controlled analgesia (PCA) for postop analgesia
Exclusion Criteria7
- Current use of gabapentin
- Unable to give consent
- epilepsy
- pregnancy
- lactation
- significant renal impairment
- galactos metabolic disorders
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Interventions
One month course of oral pregabalin commencing with a single preoperative 150md dose of pregabalin, followed by 75mg oral pregabalin BD for 7 days after surgery, then increasing to 75-150mg bd for the
One month course of oral pregabalin commencing with a single preoperative 150md dose of pregabalin, followed by 75mg oral pregabalin BD for 7 days after surgery, then increasing to 75-150mg bd for the following 21 days, a total of 28 days of pregabalin
Locations(1)
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ACTRN12608000088347