RecruitingPhase 3Phase 4ACTRN12608000181303

Detection of recombinant human luteinising hormone (rLH) as a doping agent

Detection of recombinant human luteinising hormone as a doping agent in healthy male volunteers aged 18 to 45. An open label, randomised clinical study.


Sponsor

Sydney South Western Area Health Service (SSWAHS)

Enrollment

64 participants

Start Date

Nov 23, 2004

Study Type

Interventional

Conditions

Summary

Sports anti-doping study


Eligibility

Sex: MalesMin Age: 18 YearssMax Age: 45 Yearss

Plain Language Summary

Simplified for easier understanding

This is a sports anti-doping research study investigating whether recombinant human luteinising hormone (rLH) — a hormone that could potentially be misused by athletes — can be detected in the body after administration. The goal is to develop reliable tests to identify this substance in sports drug testing. You may be eligible if: - You are a healthy male - You are between 18 and 45 years old You may NOT be eligible if: - You have a recent history of steroid use - You are female - You are outside the age range of 18 to 45 Talk to your doctor about whether this trial might be right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Half of the participants will have a 200mg injection of Nandrolone decanoate, then 3 days later a single dose of rLH 75IU or 225IU or recombinant human chorionic gonadotropin 'rhCG' 250ug or 750ug .

Half of the participants will have a 200mg injection of Nandrolone decanoate, then 3 days later a single dose of rLH 75IU or 225IU or recombinant human chorionic gonadotropin 'rhCG' 250ug or 750ug . Those given 'rhCG' will have another 100mg dose of Nandrolone decanoate the following day. The other half of the participants will be given either a single dose of either rLH 75IU or 225IU or rhCG 250ug or 750ug without the Nandrolone. Blood and urine samples will be obtained at intervals form 0 for up to 8 days.


Locations(1)

Australia

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