Arginine and wound healing in patients with critical limb ischaemia recovering from a bypass graft

This study is testing whether a diet supplemented with arginine — an amino acid that may support wound healing — can help patients with severe leg artery blockage (critical limb ischaemia) heal faster after bypass graft surgery. Participants will receive either regular hospital meals plus an arginine-enriched supplement or regular meals plus a standard nutritional supplement, to see which helps surgical wounds heal more quickly. You may be eligible if: - You are 18 years of age or older - You have been diagnosed with critical lower-limb ischaemia (severely reduced blood flow to the leg) - You are admitted to the vascular surgery unit for a bypass graft procedure - You are able to eat normally You may NOT be eligible if: - You are receiving palliative (end-of-life) care - You are in an intensive care unit - You are not eating by mouth, or require tube feeding or intravenous nutrition - You have impaired thinking or cognition that prevents you from fulfilling study requirements Talk to your doctor about whether this trial might be right for you.