Effect of statin ingestion on muscle function at rest and following acute exercise in humans
Effect of simvastatin ingestion on muscle function at rest and following acute exercise in healthy humans
The University of Melbourne
24 participants
Oct 1, 2008
Interventional
Conditions
Summary
Th eprimary purpose of this study is the examine the effect of statin medication on skeletal muscle metabolism at rest and during and after acute exercise. We hypothesise that high dose statin ingestion will lead to reductions in mitochondrial function and/or number and thus altering muscle metabolism.
Eligibility
Inclusion Criteria1
- Healthy males, (18-35yrs) normal renal, liver and thyroid function. no other mediciations for histories of diease.
Exclusion Criteria1
- abnormal renal, thyroid and liver function
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Interventions
Healthy males (18-35yrs) will ingest 80 mg/day of simvastatin for 28 days and then perform a single bout (1hr) of prolonger moderate intensiity exercise.
Locations(1)
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ACTRN12608000423314