Not Yet RecruitingPhase 4ACTRN12608000423314

Effect of statin ingestion on muscle function at rest and following acute exercise in humans

Effect of simvastatin ingestion on muscle function at rest and following acute exercise in healthy humans

Sponsor

The University of Melbourne

Enrollment

24 participants

Start Date

Oct 1, 2008

Study Type

Interventional

Conditions

Statin-induced myopathy

Summary

Th eprimary purpose of this study is the examine the effect of statin medication on skeletal muscle metabolism at rest and during and after acute exercise. We hypothesise that high dose statin ingestion will lead to reductions in mitochondrial function and/or number and thus altering muscle metabolism.

Eligibility

Sex: MalesMin Age: 18 YearssMax Age: 35 Yearss

Plain Language Summary

Simplified for easier understanding

This study is investigating how taking a statin medication (commonly used to lower cholesterol) affects muscle function at rest and after exercise in healthy young men. Some people on statins experience muscle pain, and this study aims to understand why. It is for healthy men aged 18 to 35 with normal kidney, liver, and thyroid function.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Healthy males (18-35yrs) will ingest 80 mg/day of simvastatin for 28 days and then perform a single bout (1hr) of prolonger moderate intensiity exercise.

Locations(1)

Australia

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ACTRN12608000423314