The Protein StudyThe effect of protein intake on circulating inflammatory markers in women with obesity
The effect of protein intake on circulating inflammatory markers in women with obesity
University of Otago
25 participants
Jul 15, 2008
Interventional
Conditions
Summary
Pro-inflammatory cytokines concentrations are elevated in the fasting and postprandial state and are thought to contribute to the high risk of insulin resistance and type 2 diabetes in obesity. Ingestion of protein and especially dairy protein, increases the secretion of insulin that has anti-inflammatory activity. The study aims to determine whether ingestion of dairy protein with or without carbohydrate decreases postprandial levels of pro-inflammatory cytokines in obese women. The findings will be highly relevant to the use of high -protein diets in the management of obesity and type 2 diabetes.
Eligibility
Inclusion Criteria1
- abdominally obese women Body Mass Index (BMI) > 30 and waist circumference > 88cm)
Exclusion Criteria1
- Cigarette smoking, cardiovascular disease, infections or other serious medical problems and use of some medications
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Interventions
All participants consume 2 protein meals consisting of 19.5gms of dairy protein per meal. The meals are consumed on 2 different occasions with an interval of at least 1 week between the meals.
Locations(1)
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ACTRN12608000450314