Metabolic effects of oestrogen compounds in men with low testosterone

This study is for men with prostate cancer who are receiving hormone-blocking treatment (called androgen deprivation therapy). Blocking male hormones can cause changes in metabolism, including weight gain and changes in bone density. This study tests whether a drug called raloxifene — normally used in women — can help offset some of these metabolic side effects in men by affecting the body's growth hormone system. You may be eligible if: - You are a man between 40 and 80 years of age - You have prostate cancer and have been receiving androgen deprivation therapy (hormone-blocking treatment) for at least 6 months You may NOT be eligible if: - You have been on androgen deprivation therapy for less than 6 months - Your cancer has spread to other parts of the body (metastases) - You have another type of cancer - You have diabetes - You have kidney or liver disease - You have a history of deep vein thrombosis (blood clots in the legs) Talk to your doctor about whether this trial might be right for you.