Sub-chronic administration of the selective serotonin reuptake inhibitor escitalopram in healthy volunteers: drug initiation effects and the role of serotonin in experimental anxiety.

This study is for healthy adults who want to help researchers understand how a common type of antidepressant medication (escitalopram, an SSRI) affects anxiety and mood in people who do not have an anxiety disorder. Many people starting SSRIs feel more anxious or "jittery" in the first few weeks, before the medication's benefits kick in. This study explores whether this early jitteriness also happens in healthy people, and whether the medication can reduce anxiety brought on by an experimental challenge test. You may be eligible if: - You are a healthy adult between 18 and 65 years of age - You have no current or past history of anxiety, depression, or any other mental illness You may NOT be eligible if: - You have or have had a mental illness - You have previously taken or are currently taking SSRI medication - You are pregnant or breastfeeding - You have a serious medical condition - You have had a significant head injury - You have a history of drug abuse or dependence Talk to your doctor about whether this trial might be right for you.