Investigation of Caspofungin Eye Drops for the Treatment of Fungal Eye Infections
Ocular Penetration of Caspofungin Eye Drops in the Treatment of Fungal Keratitis
Monash
30 participants
Apr 1, 2009
Interventional
Conditions
Summary
This proposed study is intended to investigate if the antifungal drug, caspofungin, when applied as an eye drop is able to penetrate into the human eyes. The use of caspofungin as an eye drops in human has never been reported. Caspofungin eye drops are anticipated to safely penetrate into the human eyes when applied as eye drops and to achieve adequate concentrations to treat fungal eye infections.
Eligibility
Inclusion Criteria1
- Patients attending for elective eye surgery (eg. cataract surgery)
Exclusion Criteria1
- Participants in whom the use of caspofungin is contraindicated (eg. pregnancy, hypersensitivity to caspofungin or its formulation, risk of clinically significant drug interactions or as per caspofungin's product information guide)
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Interventions
One drop of 0.5% Caspofungin eye drops will be administered hourly into the eye that will be operated on (commencing 4 hours before participant's elective surgery).
Locations(1)
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ACTRN12609000066280