CompletedPhase 2ACTRN12609000093280

Exogenous glucagon-like peptide-1 (GLP-1) attenuates the glycaemic response to small intestinal nutrient in the critically ill.

The effect of exogenous glucagon-like peptide-1 (GLP-1) compared to placebo on glycaemia in critically ill patients during small intestinal feeding

Sponsor

Adam Deane

Enrollment

8 participants

Start Date

Jul 1, 2008

Study Type

Interventional

Conditions

Blood Glucose

Summary

The primary objective of this study is to establish if glucagon-like peptide-1 (a hormone released from the gastrointestinal) has an effect on blood sugar levels in patients who are critically ill

Eligibility

Sex: Both males and femalesMin Age: 18 YearssMax Age: 85 Yearss

Plain Language Summary

Simplified for easier understanding

This study investigates whether a gut hormone called GLP-1 can help control blood sugar spikes in critically ill patients receiving tube feeding. It is for adult patients aged 18 to 85 who are on a ventilator in intensive care and expected to need it for more than 48 hours. The study is conducted by the medical team during your ICU stay.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Glucagon-like peptide-1 at 1.2pmol.kg.min infused at 1ml/min between t=0-270min. Participants will cross-over to the other arm (i.e. GLP-1 to control and vice-versa) on the next consecutive day (as G

Glucagon-like peptide-1 at 1.2pmol.kg.min infused at 1ml/min between t=0-270min. Participants will cross-over to the other arm (i.e. GLP-1 to control and vice-versa) on the next consecutive day (as GLP-1 is rapidly metabolised with a t1/2 < 5mins)

Locations(1)

Australia

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ACTRN12609000093280

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