The effects of memantine versus placebo on visual functions after scleral buckling for regmatogenous retinal detachment (RRD)
The effects of memantine versus placebo on visual acuity , optical coherence tomogapy (OCT) , contrast sensitivity , multifocal electroretinography (mERG) after scleral buckling for regmatogenous retinal detachment (RRD)
Tehran University of Medical sciences
60 participants
Feb 20, 2008
Interventional
Conditions
Summary
Evaluation of the neuroprotective effect of Memantine in visual function of patients with macula off RRD of less than 1 months duration. Our hypothesis was that Memantine helps for better improvement of visual function in these patientsafter successful scleral buckling.
Eligibility
Inclusion Criteria4
- Macula off rhegmatogenus retinal detachment (RRD)
- Duration<4 weeks
- Proliferative vitreoretinopathy (PVR) A ;B
- Visual acuity (V/A) < 20/200
Exclusion Criteria6
- Usage of digoxin and dextrometorphan (interacting with memantine)
- Pregnancy an nursing
- Renal disease
- Failure of surgery
- Longstanding retinal detachment (RD)
- Other macular pathology
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Interventions
intervention: Memantine tablets for treatment group for 3 weeks orally(5mg/day for the first week and 10 mg/ day for the next two weeks)
Locations(1)
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ACTRN12609000111279