Pharmacokinetics of 0.25% levobupivacaine with clonidine following caudal epidural administration in children
A non-randomised single group study on the pharmokinetics of 0.25% levobupivacaine with clonidine administered caudally in children undergoing elective sub-umbilical surgical procedures for which caudal epidural analgesia is indicated
Royal Children's Hospital
50 participants
Jan 12, 2009
Interventional
Conditions
Summary
The aim of this study is to determine how clonidine affects the absorption of levobupivacaine in children having caudal anaesthesia for sub-umbilical surgery. Our study hypothesis is that the absorption of levobupivacaine will be affected when administered in conjunction with clonidine via the caudal route.
Eligibility
Inclusion Criteria3
- Children aged under 18 years.
- Subumbilical surgery planned.
- Caudal analgesia with levobupivacaine and clonidine regarded as acceptable standard of care by treating anaesthetist (or by independent anaesthetist where conflict of interest arises between research and treating anaesthetist)
Exclusion Criteria3
- Caudal analgesia refused by parent/guardian.
- Allergy to levobupivacaine/drug solution excipients.
- Administration of levobupivacaine or clonidine via any route in 72 hours prior to, or any extra administration during, the study period.
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Interventions
Participants will recieve 0.25% levobupivacaine in a volume to be determined by the attending anaesthetist with clonidine 2mcg/mL, via the caudal route, under general anaesthesia
Locations(1)
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ACTRN12609000126213