A comparison of oral prednisolone and oral dexamethasone in children with croup: a prospective, randomised, double blinded multicentre trial
Oral Prednisolone vs oral Dexamethasone (in two different doses) in children with croup: Randomised Clinical Trial comparing the improvement in Westley Croup Score.
Dr Colin Parker
1,400 participants
Mar 27, 2009
Interventional
Conditions
Summary
This clinical trial is designed to test whether the three commonly used oral steroid treatment regimes for croup, are equally effective. Children will receive one of the three treatments, decided by a random process, and their improvement and outcomes monitored by investigators who are blinded to the treatment received.
Eligibility
Inclusion Criteria5
- Clinical diagnosis of croup
- Age 6 months to 10 years
- Weight no more than 20 kg
- Parents contactable by telephone
- Parents speak English
Exclusion Criteria5
- High clinical suspicion of an alternative diagnosis,
- Known allergy to prednisolone or dexamethasone,
- Immunosuppressive disease or treatment,
- Steroid therapy in past 14 days,
- Enrolment in this study in past 14 days
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Interventions
Group 1 - oral prednisolone 1 mg/kg oral liquid, single dose; Group 2 - oral dexamethasone 0.15 mg/kg oral liquid, single dose;
Locations(1)
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ACTRN12609000290291