The effect of pretreatment with a loading dose of intracoronary adenosine on periprocedural myonecrosis in patients undergoing percutaneous coronary intervention in the setting of non ST segment elevation acute coronary syndrome
The effect of pretreatment with a loading dose of intracoronary adenosine on periprocedural myonecrosis in patients having percutaneous coronary intervention in the setting of non ST segment elevation acute coronary syndrome.
Monash Medical Center
144 participants
Oct 1, 2008
Interventional
Conditions
Summary
Adenosine has never been studied in coronary angioplasty in the setting of non ST segment elevation acute coronary syndrome. With promising observations of the benefits of adenosine in both elective and primary angioplasty settings, we hypothesise that intracoronary adenosine may prevent myocyte death (periprocedural myonecrosis) in this groups of patients undergoing coronary angioplasty. We hypothesise that pretreatment with a intracoronary bolus dose of adenosine before coronary angioplasty decreases the amount of periprocedural myonecrosis in patients with non ST segment elevation acute coronary syndrome
Eligibility
Inclusion Criteria1
- Patients presenting with non ST segment elevation acute coronary syndrome (NSTEACS)
Exclusion Criteria1
- ST segment elevation myocardial infarction (STEMI), Cardiogenic Shock, bradycardia or Atrioventricular (AV) block, refractory ventricular arrhythmias, severe asthma, allergy to adenosine, totally occluded arteries resulting in TIMI grade 0 antegrade flow, pregnancy, unconscious or not for resuscitation,
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
Intracoronary adenosine, 4mg (ADENOCOR)made up with 4mls of normal saline, as a single bolus dose.
Locations(1)
View Full Details on ANZCTR
For the most up-to-date information, visit the official listing.
ACTRN12609000342213