RecruitingPhase 3ACTRN12609000342213

The effect of pretreatment with a loading dose of intracoronary adenosine on periprocedural myonecrosis in patients undergoing percutaneous coronary intervention in the setting of non ST segment elevation acute coronary syndrome

The effect of pretreatment with a loading dose of intracoronary adenosine on periprocedural myonecrosis in patients having percutaneous coronary intervention in the setting of non ST segment elevation acute coronary syndrome.


Sponsor

Monash Medical Center

Enrollment

144 participants

Start Date

Oct 1, 2008

Study Type

Interventional

Conditions

Summary

Adenosine has never been studied in coronary angioplasty in the setting of non ST segment elevation acute coronary syndrome. With promising observations of the benefits of adenosine in both elective and primary angioplasty settings, we hypothesise that intracoronary adenosine may prevent myocyte death (periprocedural myonecrosis) in this groups of patients undergoing coronary angioplasty. We hypothesise that pretreatment with a intracoronary bolus dose of adenosine before coronary angioplasty decreases the amount of periprocedural myonecrosis in patients with non ST segment elevation acute coronary syndrome


Eligibility

Sex: Both males and femalesMin Age: 18 Yearss

Plain Language Summary

Simplified for easier understanding

This study is looking at whether giving a dose of a drug called adenosine directly into the heart artery before a procedure to open a blocked artery (coronary angioplasty) can reduce damage to the heart muscle. The study is specifically for patients who are having the procedure due to a type of heart attack called non-ST elevation acute coronary syndrome. Adenosine has shown benefits in other heart procedures, and this study wants to see if it works here too. You may be eligible if: - You are 18 years or older - You have been diagnosed with non-ST elevation acute coronary syndrome (a type of heart attack) - You are being treated with coronary angioplasty You may NOT be eligible if: - You have had a STEMI (a more severe type of heart attack with ST elevation on ECG) - You are in cardiogenic shock - You have a very slow heart rate or heart block - You have severe asthma - You are allergic to adenosine - You are pregnant or unconscious - You have uncontrolled dangerous heart rhythms Talk to your doctor about whether this trial might be right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Intracoronary adenosine, 4mg (ADENOCOR)made up with 4mls of normal saline, as a single bolus dose.

Intracoronary adenosine, 4mg (ADENOCOR)made up with 4mls of normal saline, as a single bolus dose.


Locations(1)

Australia

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ACTRN12609000342213