Regulation of blood fat transport following a fatty test meal in lean men and men with the metabolic syndrome
Novel studies of postparandial lipoprotein metabolism in lean men and men with the metabolic syndrome
Professor Gerald Watts
45 participants
Jun 1, 2009
Observational
Conditions
Summary
The aim is to carry out a case-control study to demonstrate abnormalities in postprandial lipoprotein metabolism, in men with the metabolic syndrome (MetS) compared with lean men. A further aim is to demonstrate that postprandial lipoprotein metabolism is improved, but not normalized, in men with MetS treated with a statin.
Eligibility
Inclusion Criteria2
- All men will be aged 20-75yr and be non-smoking. 30 metabolic syndrome (MetS) men with a body mass index (BMI) <40kg/m will be recruited. The metabolic syndrome (MetS) will be defined by National Cholesterol Education Programme (NCEP) criteria as the presence of at least three of the following: waist circumference >102cm, triglycerides >1.7mmol/L, high densily lipoprotein (HDL)-cholesterol <1.05mmol/L, blood pressure >130/>85mm, and fasting glucose >6.1mmol/L. The 15 metabolic syndrome (MetS) men treated with Crestor will have a low density lipoprotein (LDL)-cholesterol <2.5mmol/L.
- age-matched normolipidaemic men with a body mass index (BMI) <25kg/m2, waist circumference <102cm, triglycerides <1.0mmol/L, high density lipoprotein (HDL)-cholesterol =1.2 mmol/L, will also be recruited.
Exclusion Criteria1
- Subjects with plasma LDL-cholesterol >5mmo/L, diabetes mellitus, genetic hyperlipidaemia (e.g. familial hypercholesterolaemia (FH), consumption of >30g alcohol/day, apolipoprotein E2/E2 genotype, macroproteinuria, creatinaemia (>120?mol/L), hypothyroidism, and hepatic dysfunction (aspartate transaminase (AST) or alanine transaminase (ALT) >2x upper limit of normal (ULN), Creatine kinase >3x upper limit of normal (ULN) in Crestor treated subjects, major systemic illness and use of steroids or other agents that may influence lipid metabolism, cardiovascular event within past 6 months, subjects on hypocaloric diets, lactose intolerance or intolerance to cream or eggs, anaemia; any significant illness that in the opinion of reviewing physician would bear on the study (e.g. heart murmur or psychiatric conditions)
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Interventions
Observational study. Imediately following a high fat test meal, intravenous D3-leucine stable isotope and two oral vitamin A capsules (50,000U each) will be used as kinetic tracers of lipoprotein metabolism. This wil be given only once and on one day only.
Locations(1)
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ACTRN12609000382279