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CompletedPhase 4ACTRN12609000584235

Impact of vitamin D status on risk of cardiovascular disease.

Impact of vitamin D status on risk of cardiovascular disease in healthy adults.

Sponsor

Department of Health

Enrollment

100 participants

Start Date

Sep 3, 2009

Study Type

Interventional

Conditions

We are studying whether vitamin D deficiency increases cardiovascular risk

Summary

The study aims to determine whether vitamin D deficiency is associated with increased cardiovascular risk and whether that risk is reversed by vitamin D replacement.

Eligibility

Sex: Both males and femalesMin Age: 30 YearssMax Age: 70 Yearss

Inclusion Criteria1

  • Healthy adults

Exclusion Criteria4

  • Treatment with 25-hydroxy vitamin D or 1,25-dihydroxy vitamin D
  • Beta-blocker medication
  • Diabetes mellitus
  • Atrial fibrillation

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Interventions

Arterial stiffness and autonomic nervous system activity will be correlated with vitamin D status in a cross-sectional study. Subjects with vitamin D deficiency (25-hydroxy vitamin D < 50 nmol/L) will

Arterial stiffness and autonomic nervous system activity will be correlated with vitamin D status in a cross-sectional study. Subjects with vitamin D deficiency (25-hydroxy vitamin D < 50 nmol/L) will be restudied 4-6 weeks after replenishment of vitamin D stores (100000 IU vitamin D orally in two doses two weeks apart).

Locations(1)

Australia

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ACTRN12609000584235