The effect of tramadol analgesia on post-operative ventilation duration in post-surgical neonates
Impact on post-operative newborn infants receiving tramadol or placebo on duration of mechanical ventilation
The Royal Children's Hospital
100 participants
Nov 1, 2009
Interventional
Conditions
Summary
Tramadol is increasingly used as an analgesic in newborn infants who require surgery. It is hypothesised that tramadol use promotes decreased exposure to other analgesic agents like morphine, some of which depress respiration. By measuring the effect of tramadol or placebo on duration of mechanical ventilation, we can determine whether or not using tramadol has a significant sparing effect for the use of opioid analgesic agents.
Eligibility
Inclusion Criteria1
- Newborn infants requiring surgery at The Royal Children's Hospital who are inpatients on the Newborn Intensive Care Unit.
Exclusion Criteria1
- Infants born less < 32 weeks' gestation or infants with congenital malformations of the nervous system.
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Interventions
Administration of tramadol infusion 2 mg/kg (in 10 mls) every six hours for five days commencing immediately post-operatively.
Locations(1)
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ACTRN12609000875202