RecruitingACTRN12609000948291

Randomized clinical trial of the influence of intraperitoneal local anesthesia on pain after laparoscopic colectomy

Randomized clinical trial of the influence of intraperitoneal local anesthesia on pain after laparoscopic colectomy.

Sponsor

Chuna-Ang University

Enrollment

60 participants

Start Date

Dec 1, 2009

Study Type

Interventional

Conditions

the patients undergoing laparoscopic colectomy

Summary

The aim of this study is to examine the effect of intraperitoneal LA on the requirement for postoperative and pain intensity after long duration of pneumoperitoneum. We also hypothesize that the timing of administration of intraperitoneal local anesthetics(LA) will affect to postoperative pain.

Eligibility

Sex: Both males and femalesMin Age: 18 YearssMax Age: 65 Yearss

Plain Language Summary

Simplified for easier understanding

This study is looking at whether injecting a numbing medicine (local anaesthetic) into the belly (abdomen) area during keyhole surgery to remove part of the colon (laparoscopic colectomy) can reduce pain after the operation. Researchers also want to find out if the timing of when the local anaesthetic is injected — at the start versus the end of the procedure — makes a difference to how much pain patients feel afterwards. You may be eligible if: - You are between 18 and 65 years old - You are scheduled to have planned (elective) laparoscopic colectomy (keyhole colon surgery) - You weigh between 45 kg and 100 kg You may NOT be eligible if: - You weigh under 45 kg or over 100 kg - You have severe heart, kidney, or liver disease - You have an allergy to local anaesthetic medicines Talk to your doctor about whether this trial might be right for you.

This is a simplified summary. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

There are three groups in total: Group I(infiltration), Group D(Double0, Group C( Control). Group I(Infiltration) : infiltration ropivacaine only at the beginning of the surgery Group D(Double) :

There are three groups in total: Group I(infiltration), Group D(Double0, Group C( Control). Group I(Infiltration) : infiltration ropivacaine only at the beginning of the surgery Group D(Double) : infiltration ropivacaine twice during the surgery (time of start and end of surgery) Immediately after creation of pneumoperitoneum and place of the first two trocars 1 mg/kg of ropivacaine in 100 ml normal saline in Group I and Group D will be sprayed on the upper surface of right and left lobe of liver and left hemidiaphragm. At the end of the operation and before withdrawing the first trocar, 100ml normal saline in Group I and 1 mg/kg of ropivacaine in 100 ml normal saline in Group D will be sprayed on the upper surface of right and left lobe of liver and left hemidiaphragm in Group D. This is one off treatment.

Locations(1)

Korea, Republic Of

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ACTRN12609000948291