The effect of transdermal testosterone gel300mcg daily on cognitive performance in older postmenopausal women: a placebo controlled trial over 26 weeks

The Primary Objective of this study is to determine whether treatment of older postmenopausal women (55 to 65 years old) with transdermal testosterone gel (Libigel Registered Trademark) which delivers 300mcg of testosterone/day, improves cognitive performance. Study Hypotheses That restoration of testosterone levels in older postmenopausal women to levels seen in younger women will result in improved verbal and visual learning and memory using a highly sensitive measure of cognitive performance (Cogstate Trademark). That this research will provide the first substantial data indicating that restoration of testosterone levels to those of younger women may protect against/delay the onset of cognitive decline.