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RecruitingACTRN12609001050246

The influence of surgery on sevoflurane brain levels and awakening after anaesthesia.

To investigate the relationship between the invasiveness of surgery and the point at which patients awaken after anaesthesia and surgery.

Sponsor

Christchurch Hospital

Enrollment

105 participants

Start Date

May 7, 2009

Study Type

Observational

Conditions

First-response time following surgery.Gall bladder problemsBowel conditionsAnaesthetics

Summary

Previous audit data has suggested the magnitude of surgery has an influence on calculated effect site sevoflurane levels at awakening. The aim of this study is to evaluate this difference using a structured anaesthetic technique so as to minimise confounding variables. As intrathecal morphine (ITM) has become a common adjunct in major surgery we are also exploring the effect of ITM on effect site sevoflurane

Eligibility

Sex: Both males and femalesMin Age: 18 YearssMax Age: 65 Yearss

Inclusion Criteria3

  • Non-emergency surgery
  • American Society of Anesthetists (ASA) 1, 2 or 3
  • Body Mass Index (BMI) less than 35

Exclusion Criteria3

  • Contra-indication to propofol.
  • Contra-indication to sevoflurane.
  • Contra-indication to fentanyl.

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Interventions

major bowel surgery and "simple" laparoscopic surgery -determining time of first-response after surgery, pain scores in Post Anaesthetic Care Unit (PACU), time to reach PACU discharge criteria, recove

major bowel surgery and "simple" laparoscopic surgery -determining time of first-response after surgery, pain scores in Post Anaesthetic Care Unit (PACU), time to reach PACU discharge criteria, recovery score. Observed, when possible, up to 48 or 76 hrs post-surgery.

Locations(1)

New Zealand

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ACTRN12609001050246