RecruitingPhase 4ACTRN12610000025033

The effect of propofol on emergence delirium in children after sevoflurane anaesthesia

The effect of propofol on emergence delirium in children after sevoflurane anaesthesia for magnetic resonance imaging (MRI). A randomized controlled trial.


Sponsor

Women's and Children's Hospital

Enrollment

250 participants

Start Date

Jan 12, 2010

Study Type

Interventional

Conditions

Summary

After anaesthesia children frquently become irritable and distressed. This is termed Emergence Delirium (ED). Sometimes this can lead to intravenous lines and surgical drains becoming dislodged. The child rarely remember this period and it rarely has any longterm consequences. A number of studies have suggested that a commonly used anaesthetic drug called propofol can be used to reduce the chance of this happening. We plan to administer a dose of propofol at the end of an anaesthetic to see whether it will reduce the rate of ED.


Eligibility

Sex: Both males and femalesMin Age: 1 YearsMax Age: 12 Yearss

Inclusion Criteria1

  • Children listed for Magnetic Resonance Imaging under general anaesthesia.

Exclusion Criteria3

  • Allergy to propofol or egg product.
  • History of Malignant Hyperpyrexia.
  • Any child due to also undergo a painful procedure or one requiring pupil dilatation.

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Interventions

We wish to examine whether administration of intravenous propofol 3mg/kg over 3 minutes at the end of a sevoflurane anaesthetic can reduce the incidence of emergence delirium in children.

We wish to examine whether administration of intravenous propofol 3mg/kg over 3 minutes at the end of a sevoflurane anaesthetic can reduce the incidence of emergence delirium in children.


Locations(1)

Australia

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ACTRN12610000025033