RecruitingPhase 4ACTRN12610000025033

The effect of propofol on emergence delirium in children after sevoflurane anaesthesia

The effect of propofol on emergence delirium in children after sevoflurane anaesthesia for magnetic resonance imaging (MRI). A randomized controlled trial.


Sponsor

Women's and Children's Hospital

Enrollment

250 participants

Start Date

Jan 12, 2010

Study Type

Interventional

Conditions

Summary

After anaesthesia children frquently become irritable and distressed. This is termed Emergence Delirium (ED). Sometimes this can lead to intravenous lines and surgical drains becoming dislodged. The child rarely remember this period and it rarely has any longterm consequences. A number of studies have suggested that a commonly used anaesthetic drug called propofol can be used to reduce the chance of this happening. We plan to administer a dose of propofol at the end of an anaesthetic to see whether it will reduce the rate of ED.


Eligibility

Sex: Both males and femalesMin Age: 1 YearsMax Age: 12 Yearss

Plain Language Summary

Simplified for easier understanding

This study is testing whether giving a small dose of a common anaesthetic drug called propofol at the end of a general anaesthetic can reduce the chance of children becoming agitated or confused when they wake up — a normal but distressing experience called emergence delirium. This can happen after anaesthesia with a gas called sevoflurane, and can sometimes cause children to pull out medical tubes or drains. You may be eligible if: - Your child is between 1 and 12 years old - Your child is scheduled to have an MRI scan under general anaesthesia You may NOT be eligible if: - Your child is allergic to propofol or egg products - Your child has a personal or family history of malignant hyperpyrexia (a rare, serious reaction to anaesthetic) - Your child is also having a painful procedure or a procedure requiring their pupils to be dilated Talk to your doctor about whether this trial might be right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

We wish to examine whether administration of intravenous propofol 3mg/kg over 3 minutes at the end of a sevoflurane anaesthetic can reduce the incidence of emergence delirium in children.

We wish to examine whether administration of intravenous propofol 3mg/kg over 3 minutes at the end of a sevoflurane anaesthetic can reduce the incidence of emergence delirium in children.


Locations(1)

Australia

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ACTRN12610000025033