A prospective Randomised Controlled Trial assessing recombinant Luteinising Hormone supplementation in patients with a relative reduction in Luteinising Hormone (LH) levels during Vitro Fertilisation/Intracytoplasmic sperm Injection (IVF/ICSI) treatment.

This study is testing whether adding a supplemental hormone called recombinant LH (luteinising hormone) to the standard IVF (in vitro fertilisation) process improves the chances of pregnancy in women whose LH levels drop significantly during the treatment cycle. A previous study found that women with a large fall in LH levels had lower pregnancy rates, so this trial will test whether replacing LH improves outcomes. You may be eligible if: - You are under 42 years old - You are undergoing IVF/ICSI using long pituitary down-regulation protocol - This is no more than your third stimulated IVF cycle - You have regular menstrual cycles - You have given your consent to participate You may NOT be eligible if: - You are an egg donor - You failed to achieve adequate suppression of your hormones (down-regulation) within 6 weeks of starting treatment - You have already taken part in this study previously Talk to your doctor about whether this trial might be right for you.