CompletedEarly Phase 1ACTRN12610000114044

A randomized double blind, placebo-controlled clinical trial with oral n-acetylcysteine in systemic sclerosis patients and assessment of skin blood flow of the hands with laser Doppler perfusion imaging

Oral N-acetylcysteine in the Treatment of Raynaud's Phenomenon Secondary to Systemic Sclerosis: a Randomized, Double-blind, Placebo-controlled Clinical Trial


Sponsor

Foundation for the support for research in the state of Sao Paulo

Enrollment

40 participants

Start Date

Aug 25, 2008

Study Type

Interventional

Conditions

Summary

analyze the effect of oral N-acetylcysteine on microcirculation by laser Doppler perfusion imaging in systemic sclerosis patients


Eligibility

Sex: Both males and femalesMin Age: 18 YearssMax Age: 65 Yearss

Inclusion Criteria1

  • Raynaud phenomenon secondary to systemic sclerosis with pain

Exclusion Criteria1

  • smokers and diabetes

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Interventions

participants will receive capsules with n-acetylcysteine 600 mg three applications per day orally for 4 weeks to be provided by a developer who did not attend the previous steps

participants will receive capsules with n-acetylcysteine 600 mg three applications per day orally for 4 weeks to be provided by a developer who did not attend the previous steps


Locations(1)

Sao Paulo, Brazil

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