A randomised double-blind, placebo-controlled trial of magnesium in patients with paroxysmal lone atrial fibrillation.

This study is testing whether taking an oral magnesium supplement every day can reduce how often people with paroxysmal lone atrial fibrillation have episodes of their heart going into an irregular rhythm. Atrial fibrillation (AF) is a condition where the heart beats irregularly, causing palpitations and discomfort. 'Lone' AF means there is no other underlying heart disease. Magnesium plays a role in heart electrical function, and low magnesium may trigger episodes. You may be eligible if: - You are 18 years of age or older - You have been diagnosed with paroxysmal lone atrial fibrillation - You have had at least 2 documented AF episodes in the past 12 months confirmed by an electrical heart tracing (ECG) You may NOT be eligible if: - You have kidney failure (serum urea above 10 mmol/L) - You have untreated overactive thyroid (hyperthyroidism) - You have atrial fibrillation associated with structural heart disease (such as valve disease, enlarged heart chambers, or cardiomyopathy) - You have active inflammatory bowel disease - You are already taking magnesium supplements - You drink more than 4 standard drinks of alcohol per day - Your AF episodes are caused by another reversible condition (such as surgery, pneumonia, or severe anaemia) Talk to your doctor about whether this trial might be right for you.