Ascending multiple doses of a novel Interluken(IL-1) agonist administered to healthy subjects

This clinical trial is testing a new experimental drug called HMPL-011 in healthy men to see if it is safe at different doses. The drug is being developed to reduce inflammation in autoimmune diseases like rheumatoid arthritis, where the immune system attacks the body's own joints. Before a drug can be tested in patients with disease, it must first be shown to be safe in healthy volunteers. You may be eligible if: - You are a healthy male between 18 and 45 years old - Your body mass index (BMI) is between 19 and 34 kg/m² You may NOT be eligible if: - You have any significant acute or chronic medical condition - You are at risk of tuberculosis (TB) - You have signs of organ damage or any significant abnormal lab results Talk to your doctor about whether this trial might be right for you.