An unblinded randomized study of influenza A/H1N1 2009 (swine flu)resistance under standard and extended duration Oseltamivir treatment

This study is comparing a standard 5-day course of Tamiflu (oseltamivir) against a 10-day course to see which is less likely to allow the influenza virus to develop resistance to the drug. Tamiflu is commonly used to treat swine flu (H1N1) and other influenza strains. Researchers are concerned that shorter treatment courses might allow the virus to mutate and become resistant, making the drug less effective in the future. You may be eligible if: - You are 5 years or older - You have tested positive for influenza A (or your doctor strongly suspects it based on symptoms) - You have a fever of 37.8°C or higher, or had one within the last 24 hours - You have at least one respiratory symptom such as cough, sore throat, or runny nose - Your symptoms started no more than 48 hours before being seen - Women of childbearing age must be using adequate contraception You may NOT be eligible if: - You are pregnant or breastfeeding - You have severe breathing problems - You have serious COPD, advanced heart failure, or significant kidney disease - You are immunocompromised or have HIV - You are currently being treated for hepatitis B or C - You have a known allergy to oseltamivir (Tamiflu) Talk to your doctor about whether this trial might be right for you.