Not Yet RecruitingPhase 4ACTRN12610000459022

How does local anesthetic airway topicalisation, for awake fiberbreoptic intubation (AFOI), affect patient reaction time?

The Psychometric effect of topical lignocaine on healthy volunteers in an awake fibre optic course, tested by complex reaction time and balance and related to plasma lignocaine levels.


Sponsor

Fremantle Hospital

Enrollment

12 participants

Start Date

Jun 19, 2010

Study Type

Interventional

Conditions

Summary

Awake fibreoptic intubation (AFOI) is the method of choice for intubation and securing of a potentially difficult airway. Routine practice worldwide involves ‘topicalisation’ (numbing) of the airway with Local Anaesthetic (LA) to enable a fiber optic camera to be advanced through the airway and into the trachea, usually with the patient awake and under no sedative influence. Currently there are no data on the effects of the LA used this way on cognitive or motor function, and patients are allowed to return home shortly after such a procedure. There is no advice given with regards to driving or operating heavy machinery despite anesthetists who have had this procedure describing ‘funny feelings’ following administration of topical LA and multiple studies that report subjective feeelings of dizzines, tingling, euphoria and dysphoria We wish to assess the impact of LA on reaction time (and hence both neural and motor function) following volunteer participation in an AFOI Course that we run half yearly for anesthetists


Eligibility

Sex: Both males and femalesMin Age: 18 YearssMax Age: 60 Yearss

Inclusion Criteria1

  • voluntary participants in an awake fibre optic course

Exclusion Criteria6

  • Known intolerance or allergy to any study drug. (Lidocaine)
  • Active psychosis or history of schizophrenia
  • Pregnancy
  • Severe heart disease, liver disease, diabetes or asthma.
  • Epilepsy
  • History of epistaxis or nasal problems

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Interventions

Lignocaine topicalization for awke fibre optic intubation. a)"Spray as you Go" topicalization with Micro Atomizer Device (MAD) b)Dose titrated to comfort with instumentation. (Difference in dose

Lignocaine topicalization for awke fibre optic intubation. a)"Spray as you Go" topicalization with Micro Atomizer Device (MAD) b)Dose titrated to comfort with instumentation. (Difference in dose noted and related to Psychometric effects and plasma levels.) c)Max dose less than 9mg/kg as per safety guidelines d)Duration from start of topicalization to intubation 30 minutes on average.


Locations(1)

Australia

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ACTRN12610000459022