How does local anesthetic airway topicalisation, for awake fiberbreoptic intubation (AFOI), affect patient reaction time?
The Psychometric effect of topical lignocaine on healthy volunteers in an awake fibre optic course, tested by complex reaction time and balance and related to plasma lignocaine levels.
Fremantle Hospital
12 participants
Jun 19, 2010
Interventional
Conditions
Summary
Awake fibreoptic intubation (AFOI) is the method of choice for intubation and securing of a potentially difficult airway. Routine practice worldwide involves ‘topicalisation’ (numbing) of the airway with Local Anaesthetic (LA) to enable a fiber optic camera to be advanced through the airway and into the trachea, usually with the patient awake and under no sedative influence. Currently there are no data on the effects of the LA used this way on cognitive or motor function, and patients are allowed to return home shortly after such a procedure. There is no advice given with regards to driving or operating heavy machinery despite anesthetists who have had this procedure describing ‘funny feelings’ following administration of topical LA and multiple studies that report subjective feeelings of dizzines, tingling, euphoria and dysphoria We wish to assess the impact of LA on reaction time (and hence both neural and motor function) following volunteer participation in an AFOI Course that we run half yearly for anesthetists
Eligibility
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Interventions
Lignocaine topicalization for awke fibre optic intubation. a)"Spray as you Go" topicalization with Micro Atomizer Device (MAD) b)Dose titrated to comfort with instumentation. (Difference in dose noted and related to Psychometric effects and plasma levels.) c)Max dose less than 9mg/kg as per safety guidelines d)Duration from start of topicalization to intubation 30 minutes on average.
Locations(1)
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ACTRN12610000459022