CompletedEarly Phase 1ACTRN12610000532000

Garlic and Candida: A Pilot study (PAThWAY)

A randomised controlled pilot study comparing the effect of oral garlic tablets compared to oral placebo tablets on vaginal colonisation with Candida in women of childbearing age with a history of vulvovaginal candidiasis


Sponsor

University of Melbourne

Enrollment

10 participants

Start Date

Jun 2, 2010

Study Type

Interventional

Conditions

Summary

This study is a pilot study to take place prior to a larger Randomised Controlled Trial (RCT) "Garlic and Candida: An Exploratory Study." The RCT proposes to investigate the biological plausibility of oral garlic reducing recurrences of vaginal thrush by reducing the vaginal colonisation of Candida albicans. The RCT will involve women taking either oral daily garlic tablets or placebo, keeping a daily diary, and self collecting daily vaginal swabs and posting them to the laboratory during the second half of their menstrual cycle. This pilot study will evaluate the methodology by assessing the tolerability of the garlic tablets, the postage of the swabs, and the daily diary. It will also include a validation study on postage of vaginal swabs.


Eligibility

Sex: FemalesMin Age: 18 YearssMax Age: 50 Yearss

Plain Language Summary

Simplified for easier understanding

This pilot study tests whether garlic tablets taken orally can reduce vaginal yeast (Candida) growth in women aged 18 to 50 who have a history of vaginal yeast infections but are currently symptom-free.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

Two garlic tablets twice a day after food for 14 days (garlic powder bulb 350mg X 2 for a daily total dose of 1400mg 4 tablets)

Two garlic tablets twice a day after food for 14 days (garlic powder bulb 350mg X 2 for a daily total dose of 1400mg 4 tablets)


Locations(1)

Australia

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ACTRN12610000532000