Treatment of asymptomatic candidiasis in pregnant women for the prevention of preterm birth: a randomised trial
Does treatment of asymptomatic candidiasis in pregnant women, with clotrimazole versus usual care, prevent preterm birth?
Northern Sydney Central Coast Area Health Service
3,208 participants
Dec 15, 2010
Interventional
Conditions
Summary
Being born too early is a leading cause of perinatal death and morbidity. This trial seeks to determine whether screening for and treating asymptomatic candidiasis in pregnancy reduces the risk of this serious health problem. The trial will discover whether a simple treatment in pregnancy can reduce preterm birth. If positive, the results will be relevant to the management of every pregnancy.
Eligibility
Inclusion Criteria1
- Pregnant women presenting for antenatal care between 12+0 and 19+6 weeks gestation with singleton pregnancies and asymptomatic candidiasis
Exclusion Criteria1
- Pregnant women: with symptomatic candidiasis, who present beyond 20 weeks gestation or have a history of hypersensitivity to clotrimazole
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
Clotrimazole vaginal pessaries (100 mg) for daily use for 6 days. Women will be advised to insert one pessary as gently and deeply as possible into the vagina while lying on her back, preferably at night, for 6 nights.
Locations(9)
View Full Details on ANZCTR
For the most up-to-date information, visit the official listing.
ACTRN12610000607077