CompletedPhase 2ACTRN12610000610033

The Effect of Combined Ephedrine and Lidocaine Pretreatment on pain and hemodynamic changes due to propofol injection

The effect of combined Ephedrine and Lidocaine pretreatment on pain due to propofol injection in patients undergoing elective surgery under general anaesthesia

Sponsor

Qazvin university of medical science

Enrollment

165 participants

Start Date

Jan 8, 2010

Study Type

Interventional

Conditions

hemodynamic changes due to propofol injection pain due to propofol injection

Summary

Objectives: Injection pain and hypotension are two main adverse effects of propofol which distresses patient. The aim of this prospective double blind study was to compare the effect of ephedrine -lidocaine combination with lidocaine and ephedrine on injection pain and hemodynamic changes due to propofol induction. Methods: 165adult patients, aged 20 to 60 yr, Patients were randomly allocated to one of 5 groups (33 patients per group): lidocaine 0.5 mg/kg(L) ,ephedrine 30microgram/kg (E30), ephedrine 70microgram/kg(E70), lidocaine0.5mg/kg -ephedrine30 microgram/kg(LE) or 2ml saline (S) intravenously.After one minute propofol 2 mg/kg into a dorsal hand vein was injected. Face pain scale and verbal rating scale, arterial blood pressure and heart rate were recorded before induction, just before intubation, and one minute after intubation.

Eligibility

Sex: Both males and femalesMin Age: 20 YearssMax Age: 60 Yearss

Inclusion Criteria2

patients with American Society of Anesthesiologists(ASA) physical status I and
II, undergoing elective surgery performed under general anesthesia

Exclusion Criteria4

patients with
difficulty in communication, those with a history of adverse response to propofol, lidocaine, or
ephedrine, and those with allergic, neurologic or cardiovascular disease and patients, who had
received an analgesic medication within 24 hr before surgery

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Interventions

Patients were randomly allocated to one of 5 groups (33 patients per group): lidocaine 0.5 mg/kg(L) ,ephedrine 30micrograms/kg (E30)ephedrine 70micrograms/kg(E70),lidocaine0.5mg/kg -ephedrine30

Patients were randomly allocated to one of 5 groups (33 patients per group): lidocaine 0.5 mg/kg(L) ,ephedrine 30micrograms/kg (E30)ephedrine 70micrograms/kg(E70),lidocaine0.5mg/kg -ephedrine30 micrograms/kg(LE) or 2ml saline (S)intravenously.participants in each group receive a single dose of the intervention treatment only.After one minute propofol 2 mg/kg into a dorsal hand vein was injected.

Locations(1)

qazvin, Iran, Islamic Republic Of

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ACTRN12610000610033