The effect of intravenous lidocaine infusion and intraperitoneal lidocaine instillation on the pain after laparoscopic appendectomy
In patients undergoing laparoscopic appendectomy, is intravenous lidocaine infusion and intraperitoneal lidocaine instillation more effective than a placebo in reducing post-operative pain?
Chung-Ang University
83 participants
Mar 1, 2010
Interventional
Conditions
Summary
Intra-peritoneal instillation of local anaesthetics in laparoscopic procedures reduces post-operative pain, analgesic requirements, the stress response and lengthens the period to first post-operative analgesic requirement. Another alternative approach to accelerate outcomes after operation is intravenous lidocaine. We hypothesized that intravenous lidocaine infusion and intraperitoneal lidocaine instillation reduce the pain after laparoscopic surgery. Therefore we investigated a comparative study on multimodal lidocaine pre emptive analgesia in laparoscopic appendectomy patients.
Eligibility
Inclusion Criteria1
- patients undergoin laparoscopic appendectomy
Exclusion Criteria1
- body weight lower than 45 kg or greater than 100 kg, history of severe underlying cardiovascular, pulmonary, renal or hepatic disease, or allergy to local anaesthetics
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Interventions
arm1:intravenous (IV) lidocaine infusion: IV lidocaine administration was performed 2 minute before orotracheal intubation. Patients in arm1 received an IV bolus injection of lidocaine (1.5 mg/kg) followed by a continuous IV infusion at 2 mg/kg/hr during the operation (60 minutes). arm2.intraperitoneal lidocaine instillation: Intraperitoneal instillation of lidocaine (total instillation dose 3.5 mg/kg) were administered immediately after the creation of the pneumoperitoneum and 10 min before the beginning of surgery.
Locations(1)
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ACTRN12610000649011