CompletedPhase 4ACTRN12610000649011

The effect of intravenous lidocaine infusion and intraperitoneal lidocaine instillation on the pain after laparoscopic appendectomy

In patients undergoing laparoscopic appendectomy, is intravenous lidocaine infusion and intraperitoneal lidocaine instillation more effective than a placebo in reducing post-operative pain?

Sponsor

Chung-Ang University

Enrollment

83 participants

Start Date

Mar 1, 2010

Study Type

Interventional

Conditions

pain following laparoscopic appendectomy

Summary

Intra-peritoneal instillation of local anaesthetics in laparoscopic procedures reduces post-operative pain, analgesic requirements, the stress response and lengthens the period to first post-operative analgesic requirement. Another alternative approach to accelerate outcomes after operation is intravenous lidocaine. We hypothesized that intravenous lidocaine infusion and intraperitoneal lidocaine instillation reduce the pain after laparoscopic surgery. Therefore we investigated a comparative study on multimodal lidocaine pre emptive analgesia in laparoscopic appendectomy patients.

Eligibility

Sex: Both males and femalesMin Age: 18 YearssMax Age: 65 Yearss

Plain Language Summary

Simplified for easier understanding

This study compares two methods of using the numbing drug lidocaine to reduce pain after keyhole surgery to remove the appendix. Participants aged 18 to 65 scheduled for laparoscopic appendectomy may be eligible to join.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

arm1:intravenous (IV) lidocaine infusion: IV lidocaine administration was performed 2 minute before orotracheal intubation. Patients in arm1 received an IV bolus injection of lidocaine (1.5 mg/kg) f

arm1:intravenous (IV) lidocaine infusion: IV lidocaine administration was performed 2 minute before orotracheal intubation. Patients in arm1 received an IV bolus injection of lidocaine (1.5 mg/kg) followed by a continuous IV infusion at 2 mg/kg/hr during the operation (60 minutes). arm2.intraperitoneal lidocaine instillation: Intraperitoneal instillation of lidocaine (total instillation dose 3.5 mg/kg) were administered immediately after the creation of the pneumoperitoneum and 10 min before the beginning of surgery.

Locations(1)

Korea, Republic Of

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ACTRN12610000649011